Post-Mortem Neuropathology of Idiopathic RBD: A Case Series
A recent publication from a large RBD cohort in Spain examined postmortem brain tissue from individuals who had RBD. This study showed there was abnormal synuclein in the cells that control atonia (muscle paralysis) during REM sleep in all the participants.
Validation of Automated Detection of REM Sleep without Atonia Using In-Laboratory and In-Home Recordings
A recent study led by NAPS investigators Drs. Erik St. Louis and Brad Boeve from Mayo Clinic validated the use of an in-home sleep recording device to detect REM sleep without atonia.
The RBD Severity Scale
The RBD Severity Scale, also known as the "IRBD-SSS" (International REM Sleep Behavior Disorder Study Group Symptom Severity Scale), is a tool used to assess the severity of REM Sleep Behavior Disorder (RBD) symptoms by evaluating the frequency and intensity of dream content, vocalizations, body movements, and potential injuries experienced by the patient, often with input from their bed partner as well.New research sheds light on REM sleep behavior disorder and its link to neurodegenerative diseases like Parkinson's. 🧠🔬💤
A Pontine-Medullary Loop Crucial for REM Sleep and its Deficit in Parkinson’s Disease
New research sheds light on REM sleep behavior disorder and its link to neurodegenerative diseases like Parkinson's. 🧠🔬💤
Does Your Body Composition Affect Your Risk of Dementia or Parkinson's?
Researchers found that higher levels of belly and arm fat are associated with increased risk of developing Alzheimer's and Parkinson's diseases, especially among those with lower muscle strength. The study showed that individuals with high belly fat had a 13% higher risk, and those with high arm fat had an 18% higher risk of these neurodegenerative diseases compared to their counterparts with lower fat levels.
RBD Question of the Week❓💤💡 How confident are you in predicting phenoconversion/transformation of neurodegenerative conditions in people with RBD?
This week, we have Drs. Roneil Malkani from Northwestern University and Ron Postuma from McGill University to answer one of our most pressing RBD questions.
Brain Waste-Clearance System Shown in People for First Time
Recently, a study from Oregon Health & Science University showed that cerebrospinal fluid flows into the brain through distinct channels called perivascular spaces and then into the brain tissue, a discovery that aligns with the glymphatic system described in mice.
Memory Loss Isn’t the Only Sign of Dementia
Memory loss is the most recognized symptom of dementia, particularly in Alzheimer's disease, but experts point out other early warning signs that are significant for types of dementia where forgetfulness isn't primary.
Here are five other common red flags to look out for.
RBD Question of the Week❓💤💡 Is there a specific treatment to prevent neurodegeneration in those with RBD?
This week, we have Drs. Roneil Malkani from Northwestern University and Ron Postuma from McGill University to answer one of our most pressing RBD questions.
Industry Roundtable | Advancing Clinical Trials for Neuroprotective Treatments Targeting Synucleinopathies
We recently wrapped up our second Industry Roundtable at the Movement Disorders Society Congress in Philadelphia.
Our focus? Advancing clinical trials for neuroprotective treatments targeting synucleinopathies.
Digital Biomarkers for Non-Motor Symptoms in Parkinson’s Disease
Wearable tech may help track non-motor Parkinson’s symptoms like sleep issues linked to REM sleep behavior disorder. NAPS will soon begin a pilot study at select sites.
RBD Question of the Week❓💤💡 Why is it important to diagnose RBD?
This week, we have Dr. Carlos Schenck, a physician who first described RBD and a member of the NAPS Scientific Advisory Board, to answer one of our most pressing RBD questions.
A Machine Learning Approach for Early Identification of Prodromal Parkinson’s Disease
A study suggests voice analysis in RBD patients may help detect early Parkinson’s progression. AI monitoring of voice, movement, and walking patterns shows promise but needs further validation.
Obsessed with Sleep
The New York Times delves into the rise of sleep optimization, noting the risks of 'orthosomnia'—an excessive focus on perfect sleep that can backfire. While aids like magnesium and gadgets help some, experts emphasize simpler habits.
RBD Question of the Week❓💤💡 What is a parasomnia?
This week, we have Dr. Carlos Schenck, a physician who first described RBD and a member of the NAPS Scientific Advisory Board, to answer one of our most pressing RBD questions.
Cognitive, Motor, and Autonomic Function Among Individuals with Serotonergic Versus iRBD
A study by Dr. Michael Howell and NAPS team at University of Minnesota found key differences between RBD triggered by antidepressants (Serotonergic RBD) and idiopathic RBD (iRBD). Follow-up ongoing to assess neurodegenerative risks.
Acetyl-DL-Leucine in Two Individuals with RBD Improves Symptoms
A recent study reported on two individuals with RBD treated with acetyl-DL-leucine (ADLL). Both had significantly decrease in severity of RBD symptoms, with improvements sustained for over 18 months. More intriguingly, both individuals had change in dopamine transporter imaging and brain imaging patterns opposite from what would be expected for Parkinson's disease, suggesting that ADLL might have a neuroprotective effect.
RBD Question of the Week❓💤💡 What is REM Sleep Behavior Disorder (RBD)?
This week, we have Dr. Carlos Schenck, a physician who first described RBD and a member of the NAPS Scientific Advisory Board, to answer one of our most pressing RBD questions.
CSF Markers of Neurodegeneration Alzheimer’s and Lewy Body Pathology in Isolated RBD (iRBD)
Researchers at Hospital Clinic of Barcelona, Spain analyzed cerebrospinal fluid (CSF) from 148 patients with isolated REM sleep behavior disorder (iRBD) to find biological signals linked to neurodegenerative diseases. The study team used advanced techniques to measure proteins, including misfolded alpha-synuclein and Alzheimer’s markers, and tracked participants longitudinally to determine whether these markers may predict disease development.
Does Your Body Composition Affect Your Risk of Dementia or Parkinson's?
Researchers found that higher levels of belly and arm fat are associated with increased risk of developing Alzheimer's and Parkinson's diseases, especially among those with lower muscle strength. The study showed that individuals with high belly fat had a 13% higher risk, and those with high arm fat had an 18% higher risk of these neurodegenerative diseases compared to their counterparts with lower fat levels.