Publications on RBD
Names in BOLD indicate a publication by a NAPS Consortium team member.
Additional Resources
Dauvilliers, Yves et al. “REM sleep behaviour disorder.” Nature reviews. Disease primers vol. 4,1 19. 30 Aug. 2018, doi:10.1038/s41572-018-0016-5
Porter, Verna R, and Alon Y Avidan. “Clinical Overview of REM Sleep Behavior Disorder.” Seminars in neurology vol. 37,4 (2017): 461-470. doi:10.1055/s-0037-1605595
St Louis, Erik K et al. “REM Sleep Behavior Disorder in Parkinson's Disease and Other Synucleinopathies.” Movement disorders : official journal of the Movement Disorder Society vol. 32,5 (2017): 645-658. doi:10.1002/mds.27018
Aurora, R Nisha et al. “Best practice guide for the treatment of REM sleep behavior disorder (RBD).” Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine vol. 6,1 (2010): 85-95.
General Information on RBD
Avidan, Alon and Porter, VR. "Overview of REM Behavioral Sleep Disorder: Clinical Manifestations, Pathophysiology and Current Treatment Options."Seminars in Neurology. 2017. Online.
Boeve, Bradley. "REM Sleep Behavior Disorder: Updated Review of the Core Features, the REM Sleep Behavior Disorder-Neurodegenerative Disease Association, Evolving Concepts, Controversies, and Future Directions."Annals of the New York Academy of Sciences. 2009. Online
Boeve, Bradley and St Louis, Erik. "REM Sleep Behavior Disorder: Diagnosis, Clinical Implications, and Future Directions."Mayo Clinic Proceedings. 2017. Online.
St Louis, Erik. "Key sleep neurologic disorders: Narcolepsy, restless legs syndrome/Willis-Ekbom disease, and REM sleep behavior disorder."Neurology Clinical Practice. 2014. Online.
"Virtual Issue on REM Sleep Behavior Disorder."Sleep. Ed. Carlos Schenck. Vol. 41, Issue 2, 2018. Online.
Link With Neurodegenerative Disease
Arnaldi D, Antelmi E, St Louis, Erik, Postuma RB, and Arnulf I. "Idiopathic REM Sleep Behavior Disorder and Neurodegenerative Risk: To Tell or not to Tell to the Patient? How to Minimize the Risk?"Sleep Medicine Reviews. Vol. 36, Pgs. 82-95, 2017. Online.
Boeve, Bradley. "Idiopathic REM Sleep Behaviour Disorder in the Development of Parkinson's Disease."The Lancet. 2013. Online.
Boeve, Bradley, Silber MH, Saper CB, Ferman TJ, Dickson DW, Parisi JE, Benarroch EE, Ahlskog JE, Smith GE, Caselli RC, Tippman-Peikert M, Olson EJ, Lin SC, Young T, Wszolek Z, Schenck, Carlos, Mahowald MW, Castillo PR, Del Tredici K, Braak H. "Pathophysiology of REM Sleep Behaviour Disorder and Relevance to Neurodegenerative Disease."Brain. 2007. Online.
Howell, Michael and Schenck, Carlos. "Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Disease."JAMA Neurology. Vol 27, No. 6, 2015. Online.
Malhotra R, Avidan, Alon. "Neurodegenerative Disease and REM Behavior Disorder."Current Treatment Options in Neurology. Vol. 14, Issue 5. pgs. 474-492, 2012. Online.
McCarter SJ, St Louis, Erik, and Boeve, Bradley. "REM Sleep Behavior Disorder and REM Sleep Without Atonia as an Early Manifestation of Degenerative Neurological Disease."Current Treatment Options in Neurology. 2012. Online.
Postuma, Ronald, Gagnon JF, Vendette M, Fantini ML, Massicotte-Marquez J, Montplaisir J. "Quantifying the Risk of Neurodegenerative Disease in Idiopathic REM Sleep Behavior Disorder."Neurology. 2009. Online.
St Louis, Erik, Boeve AR, and Boeve, Bradley. "REM Sleep Behavior Disorder in Parkinson's Disease and Other Synucleinopathies."Movement Disorders. Vol. 32, No. 5, 2017. Online.
Clinical Features and Case Series
Bliwise Donald, Rye DB. "Elevated PEM (Phasic Electromyographic Metric) Rates Identify Rapid Eye Movement Behavior Disorder Patients on Nights Without Behavioral Abnormalities."SLEEP, Vol. 31, No. 6, 2008. Online.
Ju, Yo-El, Larson-Prior L, Duntley S. "Changing Demographics in REM Sleep Behavior Disorder: Possible Effect of Autoimmunity and Antidepressants."Sleep Medicine. 2011. Online.
McCarter SJ, St Louis, Erik, Boeve, Bradley, Sandness DJ, Silber MH. "Greatest Rapid Eye Movement Sleep Atonia Loss in Men and Older Age."Annals of Clinical and Translational Neurology. 2014. Online.
McCarter SJ, St Louis, Erik, Sandness DJ, Arndt KA, Erickson MK, Tabatabai GM, Boeve, Bradley, Silber MH. "Antidepressants Increase REM Sleep Muscle Tone in Patients With and Without REM Sleep Behavior Disorder."SLEEP, Vol. 38, No. 6, 2015. Online.
McCarter SJ, St Louis, Erik, Sandness DJ, Duwell EJ, Timm PC, Boeve, Bradley, Silber MH. "Diagnostic REM Sleep Muscle Activity Thresholds in Patients with Idiopathic REM Sleep Behavior Disorder With and Without Obstructive Sleep Apnea."Sleep Medicine. 2016. Online.
McCarter SJ, St Louis, Erik, Duwell EJ, Timm PC, Sandness DJ, Boeve, Bradley, Silber MH. "Diagnostic Thresholds for Quantitative REM Sleep Phasic Burst Duration, Phasic and Tonic Muscle Activity, and REM Atonia Index in REM Sleep Behavior Disorder With and Without Comorbid Obstructive Sleep Apnea."SLEEP, Vol. 37, No. 10, 2014. Online.
McCarter SJ, St Louis, Erik, Boswell CL, Dueffert LG, Slocumb N, Boeve, Bradley, Silber MH, Olson EJ, Morgenthaler TI, Tippmann-Peikert M. "Factors Associated with Injury in REM Sleep Behavior Disorder."Sleep Medicine. 2014. Online.
Olson EJ, Boeve, Bradley, Silber MH. "Rapid Eye Movement Sleep Behaviour Disorder: Demographic, Clinical and Laboratory Findings in 93 Cases."Brain. Pgs. 331-339. 2000. Online.
Treatments
Aurora RN, Zak RS, Maganti RK, Auerbach SH, Casey KR, Chowdhuri S, Karippot A, Ramar K, Kristo DA, Morgenthaler TI; Standards of Practice Committee; American Academy of Sleep Medicine. "Best Practice Guide for the Treatment of REM Sleep Behavior Disorder (RBD)."Journal of Clinical Sleep Medicine, Vol.6, No. 1, 2010. Online.
Batalini F, Avidan, Alon, Moseley BD, Ringman JM. "Improvement of Dream Enactment Behavior Associated With Levetiracetam Treatment in Dementia With Lewy Bodies."Alzheimer Disease & Associated Disorders. 2016. Print.
McCarter SJ, Boswell CL, St Louis, Erik, Dueffert LG, Slocumb N, Boeve. Bradley, Silber MH, Olson EJ, Tippmann-Peikert M. "Treatment Outcomes in REM Sleep Behavior Disorder."Sleep Medicine. 2013. Online.
McGrane IR, Leung JG, St Louis, Erik, Boeve, Bradley. "Melatonin Therapy for REM Sleep Behavior Disorder: A Critical Review of Evidence."Sleep Medicine. 2014. Online.
Trial Planning
Boeve, Bradley; Molano JR; Ferman TJ; Lin Siong- Chi; Bieniek K; Tippmann-Peikert M; Boot B; St Louis, Erik; Knopman DS; Petersen RC; Silber MH. "Validation of the Mayo Sleep Questionnaire to Screen for REM Sleep Behavior Disorder in a Community-Based Sample."Journal of Clinical Sleep Medicine, Vol. 9, No. 5, 2013. Online.
Postuma, Ronald, Gagnon JF, Bertrand JA, Génier Marchand D, Montplaisir JY. "Parkinson Risk in Idiopathic REM Sleep Behavior Disorder: Preparing for Neuroprotective Trials."Neurology. 2015. Online.
Schenck, C, Montplaisir JY, Frauscher B, Hogl B, Gagnon JF, Postuma R, Sonka K, Jennum P, Partinen M, Arnulf I, Cochen de Cock V, Dauvilliers Y, Luppi PH, Heidbreder A, Mayer G, Sixel-Döring F, Trenkwalder C, Unger M, Young P, Wing YK, Ferini-Strambi L, Ferri R, Plazzi G, Zucconi M, Inoue Y, Iranzo A, Santamaria J, Bassetti C, Möller JC, Boeve B, Lai YY, Pavlova M, Saper C, Schmidt P, Siegel JM, Singer C, St Louis E, Videnovic A, Oertel W. "Rapid Eye Movement Sleep Behavior Disorder: Devising Controlled Active Treatment Studies for Symptomatic and Neuroprotective Therapy--a Consensus Statement From the International Rapid Eye Movement Sleep Behavior Disorder Study Group."Sleep Medicine. 2014. Online.
Boeve BF, Davis AA, Ju YE, Kantarci K, Singer W, Videnovic A. Concerns with the new biological research criteria for synucleinopathy. Lancet Neurol. 2024 Jul 23
NAPS Publications
Elliott JE, et al. Baseline characteristics of the North American prodromal Synucleinopathy cohort. Ann Clin Transl Neurol.
Elliott JE, Bryant-Ekstrand MD, Keil AT, Ligman BR, Lim MM, Zitser J, During EH, Gagnon JF, St Louis EK, Fields JA, Huddleston DE, Bliwise DL, Avidan AY, Schenck CH, McLeland J, Criswell SR, Davis AA, Videnovic A, Lee-Iannotti JK, Postuma R, Boeve BF, Ju YS, Miglis MG; for North American Prodromal Synucleinopathy (NAPS) Consortium. Frequency of Orthostatic Hypotension in Isolated REM Sleep Behavior Disorder. Neurology. 2023 Dec 12
Choudhury P, Lee-Iannotti JK, Busicescu AO, Rangan P, Fantini ML, Avidan AY, Bliwise DL, Criswell SR, During EH, Elliott JE, Fields JA, Gagnon JF, Howell MJ, Huddleston DE, McLeland J, Mignot E, Miglis MG, Lim MM, Pelletier A, Schenck CH, Shprecher D, St Louis EK, Videnovic A, Ju YS, Boeve BF, Postuma R; as the NAPS Consortium. Validation of the RBD Symptom Severity Scale in the North American Prodromal Synucleinopathy Consortium. Neurology. 2024 Feb 13
Elliott JE, Ligman BR, Bryant-Ekstrand MD, Keil AT, Powers K, Olivo C, Neilson LE, Postuma RB, Pelletier A, Gagnon JF, Gan-Or Z, Yu E, Liu L, St Louis EK, Forsberg LK, Fields JA, Ross OA, Huddleston DE, Bliwise DL, Avidan AY, Howell MJ, Schenck CH, McLeland J, Criswell SR, Videnovic A, During EH, Miglis MG, Shprecher DR, Lee-Iannotti JK, Boeve BF, Ju YS, Lim MM; North American Prodromal Synucleinopathy (NAPS) Consortium. Comorbid neurotrauma increases neurodegenerative-relevant cognitive, motor, and autonomic dysfunction in patients with rapid eye movement sleep behavior disorder: a substudy of the North American Prodromal Synucleinopathy Consortium. Sleep. 2024 Jun 13
Postuma R, Vorasoot N, St Louis EK, Pelletier A, Lim MM, Elliott J, Gagnon JF, Gan-Or Z, Forsberg LK, Fields JA, Ross OA, Singer W, Huddleston DE, Bliwise DL, Avidan AY, Howell M, Schenck CH, McLeland J, Davis AA, Criswell SR, Videnovic A, During EH, Miglis MG, Boeve BF, Ju YS, McKeon A; as the North American Prodromal Synucleinopathy (NAPS) Consortium. IGLON5 Frequency in Idiopathic REM Sleep Behavior Disorder: A Multicenter Study. Neurol NeuroimmunolNeuroinflamm. 2024 Nov 11
Reddy NV, Berns M, Berns R, Olson H, Cui E, Miglis MG, Postuma R, Boeve B, Ju YE, Howell M. Cognitive, motor, and autonomic function among individuals with serotonergic versus isolated rapid eye movement sleep behavior disorder. Sleep. 2024 Nov 8
Boeve BF, Davis AA, Ju YE, Kantarci K, Singer W, Videnovic A. Concerns with the new biological research criteria for synucleinopathy. Lancet Neurol. 2024 Jul 23
