Are you a healthcare provider, scientist or researcher?
Learn more about REM Sleep Behavior disorder diagnosis and clinical management
and explore active areas of research in synucleinopathies.
In an effort to support investigators in the field of RBD and prodromal synucleinopathies, NAPS2 is recruiting healthy male and female volunteers (aged 50+) to participate in a research study.
You may be eligible to participate if:
You do not have a history of acting out dreams at night that would suggest RBD
You do not have a diagnosis of any of the following: Parkinson’s disease or other types of parkinsonism, multiple system atrophy, dementia, or mild cognitive impairment
You are not a blood relative of a study participant that has RBD
In an effort to support new investigators in the field of RBD and prodromal synucleinopathies, NAPS2 has implemented a mentorship program for junior investigators.
NAPS2 Mentorship Program is a research program designed to aid the career development of promising early career researchers in RBD and prodromal synucleinopathies by providing:
Access to NAPS2 data, biological samples, and infrastructure
Support for futures research projects
Opportunities to network with senior investigators in this field of research
About REM Sleep Behavior Disorder
REM Sleep Behavior Disorder (RBD) is a parasomnia in which the nerve pathways that cause REM sleep atonia are disrupted. As a result, patients act out their dreams during REM sleep, sometimes resulting in violent body movements, vocalizations and emotional outcries that can cause injury both to themselves and/or their bed partners.
RBD can be categorized either as isolated RBD or symptomatic (secondary) RBD. Isolated RBD is recognized as a potential prodromal stage for an evolving synucleinopathy such as Parkinson’s disease, dementia with Lewy bodies or multiple system atrophy, offering physicians the opportunity to diagnose patients before major symptoms of these neurodegenerative disorders arise.
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Feasibility Questionnaire
The North American Prodromal Synucleinopathy Consortium is conducting a site feasibility assessment and would like to obtain information about your interest in conducting a REM Sleep Behavior Disorder (RBD) study.
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Data Request
The form is designed to facilitate the sharing of data and biospecimens among researchers while ensuring compliance with ethical standards and regulations.
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Data Sharing Poilicy
The goals of the project can be best achieved through collaborative and open access to data and biospecimens, while respecting the intellectual contributions of principal- and co-investigators. This document presents the policy for access to data, access to biospecimens, and publications.
Additional Resources
Dauvilliers, Yves et al. “REM sleep behaviour disorder.” Nature reviews. Disease primers vol. 4,1 19. 30 Aug. 2018, doi:10.1038/s41572-018-0016-5
Porter, Verna R, and Alon Y Avidan. “Clinical Overview of REM Sleep Behavior Disorder.” Seminars in neurology vol. 37,4 (2017): 461-470. doi:10.1055/s-0037-1605595
St Louis, Erik K et al. “REM Sleep Behavior Disorder in Parkinson's Disease and Other Synucleinopathies.” Movement disorders : official journal of the Movement Disorder Society vol. 32,5 (2017): 645-658. doi:10.1002/mds.27018
Aurora, R Nisha et al. “Best practice guide for the treatment of REM sleep behavior disorder (RBD).” Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine vol. 6,1 (2010): 85-95.